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Characterization of the dermal lesions induced by a purified protein from toxigenic Pasteurella multocida
Author(s) -
ELLING F.,
PEDERSEN K. B.,
HØGH P.,
FOGED N. T.
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05267.x
Subject(s) - pasteurella multocida , toxin , edema , microbiology and biotechnology , clostridium perfringens , guinea pig , intradermal injection , vascular permeability , pathology , biology , chemistry , bacteria , immunology , medicine , endocrinology , genetics
The dermonecrotic effect of purified Pasteurella multocida toxin (PMT) was studied sequentially in guinea pigs and rats. The skin reaction was initially an acute inflammatory reaction, with edema and emigration of neutrophils and a few eosinophils and diapedesis of some erythrocytes. Four hours after intracutaneous injection the vessels were congested and thrombocytes were focally attached to the endothelial wall. Twenty‐four h after the injection the inflammatory reaction appeared more severe and venules and arterioles were thrombosed. Necrotic changes were seen in hair follicles and in striated muscle fibers. Crude extracts from P. multocida and Clostridium perfringens injected intracutaneously into guinea pigs induced skin lesions qualitatively similar to the lesions induced by the purified PMT, indicating that dermonecrotic bacterial toxins may share similar biochemical properties.