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The potential intermediate role of lysosomes in oxygen free radical pathology
Author(s) -
BRUNK ULF,
CADENAS ENRIQUE
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb05261.x
Subject(s) - unpaired electron , context (archaeology) , radical , free radical theory of aging , reactivity (psychology) , chemistry , pathology , medicine , biochemistry , biology , paleontology , alternative medicine
The term “free radical” refers to atoms or groups of atoms containing a single unpaired electron occupying an outer orbital. This unpaired electron lends the molecule distinct chemical and physical properties such as its high reactivity and magnetic moment, respectively. Some relevant advances in medical research have encompassed O 2 radicals and other toxic derivatives of O 2 . These reactive O 2 species were shown to play a significant role in a wide spectrum of pathological states (see Halliwell & Gutteridge , 1985; Flohé 1986; Kensler & Taffe , 1986; McCord , 1986), though the measurement of free radical activity in clinically‐accesible material has been unsatisfactory ( Dormandy , 1986). This overview provides only a framework of information to assist the reader on some relevant topics on free radical pathology, which by no means can cover the multiple aspects of the medical literature in this context. The reader is referred to several articles which cover particular features of free radical biology and medicine ( Chance et al. , 1979; Pryor , 1976–1984; Fridovich , 1983; Jamieson et al , 1986; Kensler & Taffe , 1986; McCord , 1986; Weiss , 1986).