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Neutrophil migration in vivo and in vitro in healthy neutropenic subjects
Author(s) -
KoivurantaVaara PäVi,
Repo Heikki
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb00960.x
Subject(s) - neutropenia , in vivo , chemotaxis , in vitro , granulocyte , peripheral blood , immunology , medicine , absolute neutrophil count , neutrophile , leukopenia , biology , inflammation , toxicity , biochemistry , receptor , microbiology and biotechnology
Migration of polymorphonuclear leukocytes (PMN) was studied in six healthy subjects with neutropenia (peripheral blood neutrophil count ≥ 1.5 times 10 9 /1). Determined as migration differentials, chemotactic and chemokinetic responsiveness tended to be higher in the neutropenic group. Despite this slight tendency to increased responsiveness in vitro , migration in vivo proceeded more slowly in the neutropenic group than in the control group: at 12 hours the leukocyte counts in the skin chamber media were significantly lower, whereas at 24 hours they were nearly normal. Our results show that PMN migration in healthy neutropenic subjects is different from that in healthy non‐neutropenic subjects. These differences should be taken into account in the evaluation of the role of aberrant PMN migration in the development of infectious episodes in a neutropenic patient.