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Premalignant and malignant oral lesions are associated with changes in the glycosylation pattern of carbohydrates related to ABH blood group antigens
Author(s) -
Dabelsteen Erik,
Clausen Henrik,
Holmstrup Palle,
Reibel Jesper
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb00948.x
Subject(s) - antigen , abo blood group system , pathology , oral lichen planus , dysplasia , immunohistochemistry , biology , epithelium , monoclonal antibody , malignancy , epithelial dysplasia , h antigen , basal (medicine) , staining , oral mucosa , antibody , microbiology and biotechnology , immunology , medicine , endocrinology , insulin
The distribution of carbohydrate structures related to the ABO(H) blood group antigen system was studied in biopsies from eight squamous cell carcinomas, and eight erythroplakias with epithelial dysplasia. Twenty oral lesions without histological evidence of malignancy (13 lichen planus lesions and 7 homogeneous leukoplakias) were also examined. The distribution of Le x , Le y , H type 2 chain, and N‐acetyllactosamine, all type 2 chain carbohydrate structures, was investigated by immunohistological stainings using monoclonal antibodies with selected specificity. The histological pattern of expression of these antigens in the benign lesions was similar to that of normal oral mucosa, i.e. expression of: N‐acetyllactosamine on basal cells, H antigen on parabasal cells, and Le x and Le y on spinous cells. However, lesions with epithelial dysplasia showed H antigen on all spinous cells, and often also on basal cells, with expression of Le x and Le y restricted to the most superficial part of the epithelium above the H‐positive cell layers. In carcinomas most cells were negative for H antigen but were positive for Le y and Le x in 5 out of 8 cases.