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Ultrastructure of psoriatic epidermis
Author(s) -
Jahn H.,
Nielsen E. Holm,
Elberg J. J.,
Bierring F.,
RØNne M.,
Brandrup F.
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb00936.x
Subject(s) - stratum corneum , stratum granulosum , ultrastructure , epidermis (zoology) , corneocyte , stratum spinosum , stratum , vesicle , biology , chemistry , anatomy , microbiology and biotechnology , biochemistry , membrane , paleontology , genetics
The ultrastructure of human affected and unaffected psoriatic epidermis was studied in skin biopsies from 5 patients and 3 normal controls. Transmission electron microscopic investigations revealed abnormalities in all cell layers of the affected epidermis. Common to psoriatic keratinocytes from affected epidermis was the reduction of tonofilaments. The essential ultrastructural changes were located in the stratum granulosum and stratum corneum. Thus, abscence of the fusion between the keratohyalin granules and the tonofilaments was found in stratum granulosum. The keratinocytes of the stratum corneum showed a large accumulation of ribosomes and vesicles resembling lipid vesicles.