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Effects of bilirubin on murine peritoneal and spleen cells
Author(s) -
Vetvickka Vaclav,
Fornusek LUbor,
Sima Petr,
Bilej Martin,
Taborsky Ludek,
Riahova Blanka,
Simeckova Jana,
Miler Ivo
Publication year - 1988
Publication title -
apmis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0903-4641
DOI - 10.1111/j.1699-0463.1988.tb00928.x
Subject(s) - bilirubin , peritoneal cavity , spleen , medicine , endocrinology , receptor , biology , immunology , anatomy
The effect of bilirubin on murine peritoneal and spleen cells was investigated. Bilirubin was found to have a strong and rapid effect on the expression of various kinds of Fc receptors on peritoneal macrophages. Significant changes were observed 30 min after the infection of bilirubin. The return to normal values was not observed earlier than after 24 h. The effect of bilirubin on Fc receptor expression of splenic macrophages was less pronounced. Expression of la antigen on macrophages was not influenced by bilirubin. The changes in percentage of slg + and Thy 1.2 + lymphocytes reflect a change in the ratio of T to B cells in the peritoneal cavity, as bilirubin caused 40% increase in numbers of B cells and a similar decrease in numbers of T cells. The percentage of splenic B lymphocytes was not influenced by bilirubin injection; but the ratio of T helper to suppressor cells was altered.