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COMPARISON OF RESISTANCE TYPES IN ENTEROBACTER CLOACAE 1977 AND 1985
Author(s) -
SØGaard PER,
Togsverd EVA,
Mansa BENDT
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1987.tb03128.x
Subject(s) - enterobacter cloacae , carbenicillin , microbiology and biotechnology , cefotaxime , enterobacter , cephalosporin , cefuroxime , biology , plasmid , enterobacteriaceae , antibiotics , gene , ampicillin , escherichia coli , genetics
A collection of Enterobacter cloacae strains from Odense University Hospital from 1977 were compared with a collection from 1985 as regards acquired resistance traits. Among the strains with carbenicillin (Ca) resistance, the number of multiresistant strains decreased while the number with sole Ca‐resistance increased. In 1977, a high proportion of the Ca‐resistant (Ca‐r) strains had plasmid‐mediated β‐lactam resistance, but in 1985 the Ca‐r strains were completely dominated by organisms with elevated amounts of chromosomally‐mediated β‐lactamase. The latter, but not the former, strains were resistant to the newer cephalosporins ( e.g. cefotaxime (Ctax)). The consumption of Ctax and cefuroxime increased from 0 kg in 1977 to 7.0 kg in 1985. It is therefore probable that this increase was the cause of the change in occurrence of the resistance types. Ninety‐one % of the Ca‐r strains were isolated from urinary samples in 1977. The percentage was only 31 in 1985. This change, concomitant with the increase in Ctax‐r strains, can probably be explained by the better conditions for selection of Ctax‐r mutants, producing greater amounts of chromosomal β‐lactamase, in wounds and respiratory tract than in urine.