Premium
IMMUNOLOGICAL RELATION BETWEEN SERUM ANTIBODIES AGAINST PNEUMOLYSIN AND AGAINST STREPTOLYSIN O
Author(s) -
Kanclerski KRZYSZTOF,
GranstrÖM MARTA,
MÖLlby ROLAND
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1987.tb03119.x
Subject(s) - pneumolysin , streptolysin , streptococcus pneumoniae , titer , antibody , microbiology and biotechnology , immunology , antibody titer , hemolysin , biology , virulence , bacterial protein , bacteria , antibiotics , biochemistry , genetics , gene
The immunological relation between serum antibodies to pneumolysin and to streptolysin O was studied in patients with pneumococcal pneumonia (n=40), patients with infections due to β‐haemolytic streptococci (n=35), healthy human controls (n=60) and in rabbits immunized with pneumolysin. There was no correlation between anti‐pneumolysin and anti‐streptolysin O titers (r=‐0.279). The distribution of anti‐pneumolysin titers in patients with high anti‐streptolysin O titers did not differ from healthy controls. However, there was a tendency to increased or rising anti‐streptolysin O titers in patients with pneumococcal infection. Antibodies obtained during pneumococcal infection might thus give false‐positive reactions in the streptolysin O neutralization test. Serum antibodies to streptolysin O do not cross‐react with pneumolysin in an ELISA. The pneumolysin ELISA for detection of pneumococcal disease will therefore not be disturbed by false‐positive reactions due to antibodies directed against β‐haemolytic streptococci.