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IN VITRO SUSCEPTIBILITY OF CAMPYLOBACTER PYLORIDIS TO CIMETIDINE, SUCRALFATE, BISMUTH AND SIXTEEN ANTIBIOTICS
Author(s) -
Andreasen Jan Jesper,
Andersen Leif Percival
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1987.tb03103.x
Subject(s) - sucralfate , campylobacter , cimetidine , bismuth , antibiotics , in vitro , microbiology and biotechnology , medicine , chemistry , pharmacology , gastroenterology , biology , bacteria , biochemistry , genetics , organic chemistry
The in vitro susceptibility of recent Danish human clinical isolates of Campylobacter pyloridis to cimetidine, sucralfate, bismuth subsalicylate and sixteen antimicrobial agents was determined by an agar‐dilution technique. Benzylpenicillin was the most active drug (MIC 90 =0.1 μg/ml); ampicillin, erythromycin, gentamicin and ciprofloxacin were slightly less active. All strains were resistant to 100 μg sulfamethizole, and nalidixic acid also had little activity on weight basis. Of the three anti‐peptic ulcer drugs, bismuth subsalicylate was most active (MIC 90 25 μg/ml), but sucralfate and cimetidine also had antibacterial activity, although only little (MIC 90 3200 μg/ml).