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PROTEIN I SEROTYPE OF SERUM‐RESISTANT VERSUS SERUM‐SENSITIVE NEISSERIA GONORRHOEAE STRAINS
Author(s) -
ØDum LARS,
Buchanan THOMAS M.,
Knapp JOAN S.
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1987.tb03079.x
Subject(s) - serotype , neisseria gonorrhoeae , microbiology and biotechnology , penicillin , biology , virology , antibiotics , neisseriaceae
In order to characterize serum‐resistant and serum‐sensitive strains of N. gonorrhoeae , the protein I serotype, auxotype, and penicillin susceptibility of 128 strains were tested. Sensitivity to the complement‐dependent bactericidal activity of normal human serum was highly associated with protein I serotype (p<0.001). Thus 85% of serotype 1–3 strains were serum‐resistant, whereas 86% of serotype 8 strains and all strains with serotypes 8 + 9 or 9 were serum‐sensitive. Serum‐resistance or sensitivity for a given serotype was independent of auxotype. The susceptibility to penicillin within the serotypes 1 – 3 was significantly associated with auxotype (p = 0.0016); all AHU‐ (requirement for arginin, hypoxanthine and uracil) strains had MICs of penicillin of 0.04 μg/ml or less and were serotypes 1 – 3. Among the non‐AHU‐strains, serotype 9 was significantly more penicillin susceptible than the other serotypes (p<0.003).