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SODIUM TAUROCHOLATE‐INDUCED ACUTE PANCREATITIS IN PIGS
Author(s) -
LIUM B.,
RUUD T. E.,
PILLGRAMLARSEN J.,
STADAAS J. O.,
AASEN A. O.
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1987.tb00055_95a.x
Subject(s) - aprotinin , acute pancreatitis , pancreatitis , pancreatic duct , medicine , abdominal cavity , parenchyma , gastroenterology , anesthesia , surgery , pathology
Acute pancreatitis was induced in anesthetized pigs by injection of Na‐taurocholate into the pancreatic duct. The pigs were allocated to 4 groups. One group remained untreated while the other groups received either C 1 ‐inhibitor, aprotinin or methyl‐prednisolone intravenously as pretreatment. Extensive necroses of the pancreatic parenchyma, peripancreatic oedema and accumulation of large amounts of fluid in the abdominal cavity developed within a few hours in all experimental groups. Pretreatment significantly improved hemodynamics and increased the survival rate at 6 hours. It is concluded that the most essential effect of the pretreatments were reduction of proteolytic activities which are secondary to the pancreatic lesions.