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SIGNET‐RING CELLS IN ADVANCED GASTRIC CANCER A Clinical, Pathological and Histochemical Study
Author(s) -
SANTINI DONATELLA,
BAZZOCCHI FLORIANO,
MAZZOLENI GUIDO,
RICCI MONICA,
VITI GIULIANO,
MARRANO DOMENICO,
MARTINELLI GIUSEPPE
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1987.tb00035_95a.x
Subject(s) - signet ring cell , pathological , signet ring cell carcinoma , cancer , pathology , medicine , adenocarcinoma
A pathological and histochemical study on the presence of signet‐ring cells (SRC) in 108 advanced gastric cancer (AGC) has been evaluated. According to Laurén 's classification, 59 were of intestinal (I) and 49 of diffuse (D) type. The amount of SRC seems to be a prognostic parameter in D‐carcinoma: the 5‐year survival rate was 49% and 22% in cases with 1–24% and 75–100% SRC, respectively. Histochemically, in our series of SRC D‐carcinoma the quality of mucin secretion of SRC closely resembled the goblet cells of intestinal metaplasia. The histogenetic origin of D‐gastric carcinoma was discussed.