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SYNAPTOPHYSIN – AN IMMUNO‐HISTOCHEMICAL MARKER FOR CHILDHOOD NEUROBLASTOMA
Author(s) -
MIETTINEN MARKKU,
RAPOLA JUHANI
Publication year - 1987
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1987.tb00026_95a.x
Subject(s) - synaptophysin , neuroblastoma , pathology , biology , medicine , immunohistochemistry , genetics , cell culture
Synaptophysin, an integral membrane glycoprotein of presynaptic vesicles, was tested as an immuno‐histochemical marker for childhood neuroblastoma. Synaptophysin immuno‐reactivity was found in all neuroblastomas (6/6), but not in the other small round‐cell tumors to be considered in its differential diagnosis. Thus, rhabdomyosarcomas (0/5), lymphomas (0/4), or Ewing's sarcomas (0/2) were negative for synaptophysin. The results suggest that synaptophysin is a useful marker for neuroblastoma, and it should belong to the marker panel used for the differential diagnosis of small round‐cell tumors of childhood.