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EFFECT OF ENCEPHALOMYOCARDITIS (EMC) VIRUS ON MURINE FOETAL AND PLACENTAL GROWTH MONITORED BY QUANTIFICATION OF MATERNAL PLASMA LEVELS OF PREGNANCY‐ASSOCIATED MURINE PROTEIN‐2 AND α‐FETOPROTEIN
Author(s) -
Hau J.,
Buschard K.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1986.tb03063.x
Subject(s) - pregnancy , placenta , alpha fetoprotein , andrology , biology , medicine , endocrinology , fetus , genetics , hepatocellular carcinoma
The present study demonstrates that i) pregnant mice seem to be more sensitive to encephalomyocarditis (EMC) infection than non‐pregnant mice, and ii) the infection results in significantly increased maternal plasma levels of insulin and pregnancy‐associated murine protein‐2 (PAMP‐2), of placental origin, and α‐fetoprotein (AFP), of foetal origin. Maternal plasma levels of PAMP‐2 and AFP are correlated with placental and foetal growth respectively. This indicates that the EMC infection and the increased peripheral insulin levels lead to increased growth of the foetoplacental unit.