Premium
POPULATION ANALYSES OF THE SUSCEPTIBILITY TO CIPROFLOXACIN OF EIGHT CLINICAL STRAINS OF PSEUDOMONAS AERUGINOSA
Author(s) -
GernerSmidt P.,
Fuursted K.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1986.tb03052.x
Subject(s) - ciprofloxacin , pseudomonas aeruginosa , ofloxacin , microbiology and biotechnology , antibiotics , population , biology , mutant , quinolone , pseudomonas , pseudomonadales , bacteria , genetics , gene , medicine , environmental health
Population analyses of the susceptibility to ciprofloxacin of eight strains of Pseudomonas aeruginosa , including mucoid strains and strains resistant to aminoglycosides or anti‐Pseudomonas beta‐lactams, were carried out. All strains were sensitive as judged by the broth‐dilution technique, but four strains were found to yield resistant mutants with a frequency of less than 10 −6 . Two strains yielded mutants homogeneously sensitive to ciprofloxacin at a level 8–16 times the MIC of the parent strains. Two other strains yielded mutants resistant to different higher concentrations of ciprofloxacin. One of these mutants was examined for production of ciprofloxacin‐inactivating enzyme; no enzyme production could be detected. Cross‐resistance was found with another quinolone antibiotic, ofloxacin, but not with aminoglycosides or beta‐lactam antibiotics.