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THE ANTIBIOTIC EFFECT OF THE ANTI‐DEPRESSIVE DRUG FEMOXETINE AND ITS STEREO‐ISOMERIC ANALOGS ON DIARRHOEA PRODUCING ENTEROBACTERIACEAE
Author(s) -
Kristiansen JETTE E.,
Mortensen IDA,
Gaarslev K.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1986.tb03027.x
Subject(s) - microgram , enterobacteriaceae , antimicrobial , antibiotics , chemistry , drug , membrane , microbiology and biotechnology , pharmacology , biology , escherichia coli , biochemistry , in vitro , gene
The present investigation has been undertaken to illustrate the antibacterial effect on 20 diarrhoea producing enterobacteriaceae of an anti‐depressive drug available as femoxetine and its three analogs. It has been shown that the stereo‐isomeric trans forms of femoxetine are more than twice as active as the cis forms and inhibited all the strains below 400 μg/ml (1.2 mM). The two cis compounds only inhibited 11 and 9 of the 20 strains respectively in the investigated area 100 μg/ml – 800 μg/ml (0.3 mM – 2.4 mM). Our investigations point out that the bacterial cell has a target for psychopharmacologically active agents. Thus the known psychopharmaca and their stereo‐isomeric analogs may represent a pool of potentially new antimicrobial drugs. Furthermore the bacterial model may be useful as a model system in the study of the interaction of neuropharmacological agents and other membrane active compounds with biological membranes.