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PRIMARY PARATHYROID HYPERPLASIA OF WATER‐CLEAR CELL TYPE. TRANSFORMATION OF WATER ‐ CLEAR CELLS INTO CHIEF CELLS
Author(s) -
Persson S.,
Hansson G.,
Hedman I.,
Tisell L.E.,
WidE̊Ehn S.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1986.tb03010.x
Subject(s) - parathyroid chief cell , lipofuscin , hyperplasia , gastric chief cell , pathology , staining , chemistry , cell , medicine , parathyroid hormone , calcium , biochemistry , stomach , gastric mucosa
An exceptional case of water‐clear cell hyperplasia (WCCH) of the parathyroid glands is presented. Parathyroid tissue was excised at three operations during a period of twenty years before the patient eventually became normocalcemic. Microscopic evaluation of the parathyroids from the first operation showed typical WCCH‐findings. However, the parathyroid tissue excised at the last operation was composed of chief cells. There were calcifications and even bone formation. A pigment with the staining and electron‐microscopic characteristics of lipofuscin was found in abundance. There were also a few oxyphils. This case shows that clear cells, originally derived from chief cells, can transform into chief cells again.