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BRONCHIAL CARCINOIDS AND PHAEOCHROMOCYTOMAS
Author(s) -
ElSalhy MAGDY,
Lundqvist MONALILL,
Wilander ERIK
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1986.tb02988.x
Subject(s) - enolase , argentaffin , pathology , serotonin , immunohistochemistry , cytoplasm , biology , medicine , microbiology and biotechnology , receptor
A comparative study of bronchial carcinoids (9 cases) and phaeochromocytomas (8 cases) was performed. Both types of tumour exhibited neuron‐specific enolase (NSE) immunoreactivity and an argyrophil reaction, and displayed a few scattered argentaffin and serotonin immunoreactive tumour cells. In addition, four of the nine bronchial carcinoids and six of the eight phaeochromocytomas were S‐100 protein immunoreactive. The stained cells were located mainly in the periphery of the tumour cell aggregates and possessed long cytoplasmic processes surrounding unreactive tumour cells. The similarity between the two tumour types, especially in their morphology and S‐100 protein immunoreactivity, indicates that bronchial carcinoids, or at least some of them, are histogenetically closely related to phaeochromocytomas and might derive from the peripheral nervous system.