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FAT NECROSIS IN HUMAN ACUTE PANCREATITIS
Author(s) -
Aho HEIKKI J.,
Sternby BERIT,
Nevalainen TIMO J.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1986.tb02970.x
Subject(s) - fat necrosis , adipose tissue , necrosis , pancreatitis , colipase , lipase , pancreas , acute pancreatitis , medicine , pathology , endocrinology , biology , triacylglycerol lipase , enzyme , biochemistry
Localization of phospholipase A 2 , lipase and colipase immunoreactivity were studied in paraffin embedded tissue sections. The samples were taken from the pancreas of 12 patients suffering from acute haemorrhagic necrotizing pancreatitis, and from diseased adipose tissue of 7 patients suffering from traumatic mammary fat necrosis. Peroxidase‐antiperoxidase immunohistology revealed consistent positive reaction against phospholipase A 2 , lipase and colipase at the border of fat necrosis in pancreatic interlobular adipose tissue and in peripancreatic, mesenterial and retroperitoneal fat. The fat necroses of the breast were devoid of reaction. The results support the idea that in addition to lipase colipase and phospholipase A 2 participate in the development of fat necrosis in acute pancreatitis. Pancreatic lipolytic enzymes are not present in the adipose tissue in mammary fat necrosis.