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CORRELATION BETWEEN DEFICIENCY OF IMMUNOGLOBULIN SUBCLASS G3 AND Gm ALLOTYPE
Author(s) -
Grubb RUNE,
Hallberg TORGNY,
HammarstrÖM LENNART,
Oxelius VIVIANNE,
Smith C. I. EDVARD,
SÖDerstrÖM RUZENA,
SÖDerstrÖM TOMMY
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1986.tb02110.x
Subject(s) - allotype , subclass , haplotype , linkage disequilibrium , polyclonal antibodies , antibody , immunology , biology , genotype , genetics , gene
Gm allotypes were investigated in 63 Swedes: 46 females and 17 males, in whom serum IgG3 was below 0.35 g/l. Both monoclonal antibodies and polyclonal antisera were used for the quantification. Concentrations of the other IgG subclasses were within the age‐related normal ranges. The distribution of the IgG 1 genetic markers Glm(a,x,f) differed markedly from that observed in normal Swedes (p < 0.001). Thus Gl m(a) was present in 60 subjects as compared to an expected 36, and phenotype Gl m(‐f) in 34 subjects as against an expected 8. The mean IgG3 concentration was numerically lower in the Gl m(‐f) group than in the Gl m(+f) cohort, and individuals with IgG3 levels 0.10 g/l were more frequent in the Gl m(‐f) group. Among Caucasians, G3m 8 is in linkage disequilibrium with G lm 2 and our interpretation is that the haplotype Gl m a:ax G2m −n G3m 8 is markedly increased in individuals with IgG3 deficiency.