Premium
THE TISSUE DISTRIBUTION OF NK‐9 POSITIVE LYMPHOID CELLS INCLUDING NK AND AK CELLS AND THEIR PRECURSORS
Author(s) -
Nieminen PEKKA
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1986.tb02100.x
Subject(s) - germinal center , cytotoxic t cell , lymph node , lymphatic system , spleen , interleukin 21 , biology , lymph , tonsil , immunology , interleukin 12 , pathology , lymphocyte , antigen , b cell , medicine , antibody , cd8 , in vitro , biochemistry
The distribution of NK‐9 antigen presenting cells in human lymphoid tissues including spleen, tonsil, lymph node, and thymus was studied. The staining were done on formalin‐fixed, histological sections. In peripheral blood NK‐9 antigens are expressed on allospecific (CTL) and nonspecific (NK and AK) cytotoxic lymphocytes. In lymphoid tissues, the distribution of NK‐9 positive cells was definitely different from “normal” T cell distribution, measured by pan T monoclonal markers. In tonsils and lymph nodes NK‐9 positive cells were mainly located in and around germinal centers. However, only a proportion of these areas were NK‐9 positive. In spleen NK‐9 positive cells were located mainly in periarteriolar lymphocyte sheats and in germinal centers. Thymuses were practically NK‐9 negative. These results support the earlier suggestions that cytotoxic cells take part in the immunoregulation in lymphoid tissues.