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INTRATHECAL SYNTHESIS OF ANTIBODIES TO STAPHYLOCOCCAL ANTIGENS IN MULTIPLE SCLEROSIS PATIENTS
Author(s) -
Aasjord PER,
Nyland HARALD,
Haaheim LARS R.
Publication year - 1986
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1986.tb02097.x
Subject(s) - multiple sclerosis , intrathecal , antigen , antibody , immunology , medicine , anesthesia
Human serum and cerebrospinal fluid (CSF) antibodies against three staphylococcal antigens were measured using the ELISA technique. Antibody levels in sera from patients with multiple sclerosis (MS) were lower than those found in sera from patients with other neurological diseases (OND) and from healthy individuals (N). The CSF antibody mean titres for patients with relapsing remittent MS were about twofold higher than those found for the other groups. Both serum and CSF antibodies were of the IgG class while IgM could only be detected in serum samples. Elevated IgG‐indexes, indicating intrathecal immunoglobulin synthesis, were found only among individuals in the MS patient groups. Some of the patients also had elevated indexes of specific antibodies to the staphylococcal antigens used, i.e. lipoteichoic acid (LTA), peptidoglycan (PG) and β‐ribitol teichoic acid (β‐RTA). This indicates that some MS patients have synthesized staphylococcal antibodies intrathecally.