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A HISTOMORPHOMETRIC ANALYSIS OF SUBCHONDRAL BONE IN JUVENILE ARTHROPATHY OF THE DOG KNEE
Author(s) -
HOLM I.E.,
BÜNGER C.,
MELSEN F.
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1985.tb03954.x
Subject(s) - subchondral bone , juvenile , medicine , arthropathy , anatomy , orthodontics , osteoarthritis , articular cartilage , pathology , biology , alternative medicine , genetics
Subchondral bone changes in arthropathy were investigated in an animal model using mongrel dog knees. Unilateral arthritis of the knee was induced by repeated intra‐articular instillations of Carragheenin solution in 14 mongrel puppies. Histomorphometric analysis of cartilage and bone was performed blindly in both knees of each dog. Arthritis resulted in a significant increase in the joint cartilage thickness and a significant decrease in subchondral epiphyseal trabecular bone volume (VTB%) and trabecular thickness (TRTH), suggesting negative bone balance. No significant changes in osteoid surfaces (OS%) and resorptive surfaces (RS%) were found. The dynamic parameters suggest an increased bone turnover in the arthritic subchondral bone.