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INFLAMMATORY CELLS IN 256 WALKER TUMOUR GROWING IN THE STOMACHS OF RATS
Author(s) -
BRØYN T.,
STORVIK H.,
SVENNEVIG J. L.
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1985.tb03949.x
Subject(s) - parenchyma , pathology , peripheral blood mononuclear cell , inflammatory cell , stroma , inflammation , cell , biology , medicine , immunology , in vitro , immunohistochemistry , biochemistry , genetics
The present study was undetaken in order to determine the relative number of inflammatory cells in Walker 256 tumour implanted in the gastric mucosa of the rat. Inflammatory cells were found in all tumours, the relative content ranging from 5–21 (mean 12 %), which is comparable to findings in human intestinal tumours. Approximately 80 % of the inflammatory cells were mononuclear (lymphocytes, plasma cells and macrophages); less than 20 % were polymorphonucleated (neutrophils and eosiniphils). Both the number of inflammatory cells and the composition of the cell infiltrates changed during the tumour growth. The highest proportion was found on day 6 after implantation. In addition to the inflammatory cells within the tumor parenchyma, a large number of inflammatory cells were found in the tumour stroma. Possible mechanisms for the inflammatory cell reaction within and around the experimental tumours are discussed.