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CHANGES OF BLOOD GROUP ANTIGENS IN PREMALIGNANT AND MALIGNANT LESIONS OF THE HUMAN EXOCERVIX
Author(s) -
Teglbjærg C. Stubbe,
Norrild B.,
Dabelsteen E.
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1985.tb03933.x
Subject(s) - antigen , epithelium , immunofluorescence , pathology , basal (medicine) , malignant transformation , cervical cancer , malignant cells , biology , cancer , medicine , immunology , antibody , endocrinology , insulin
In this preliminary study the distribution of blood group A‐ and H‐antigens and their structural precursor N‐acetyllactosamine in normal, pre‐malignant and malignant squamous epithelium were investigated using the immunofluorescence technique. In normal cervical epithelium the basal cells and few parabasal cells expressed N‐acetyllactosamine. The parabasal and lower spinous cells expressed the H‐antigen and the upper spinous layer expressed the A‐antigen. All pre‐malignant and malignant lesions showed irregular decrease in contents of A‐ and H‐antigens. N‐acetyllactosamine was either completely lost or found to accumulate in these lesions, and it is suggested that this antigen could be a valuable tool in the diagnosis of cervical cancer.