Premium
IMMUNIZATION OF MICE WITH THE FIBRONECTIN‐BINDING PROTEIN AND CLUMPING FACTOR FROM STAPHYLOCOCCUS AUREUS : ANTIBODY RESPONSE AND RESISTANCE AGAINST INTRAPERITONEAL INFECTION
Author(s) -
ESPERSEN F.,
CLEMMENSEN I.
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1985.tb02922.x
Subject(s) - staphylococcus aureus , microbiology and biotechnology , antibody , immunization , antigen , fibronectin , immunology , biology , intraperitoneal injection , staphylococcal infections , protein a , staphylococcus , virology , bacteria , biochemistry , pharmacology , genetics , extracellular matrix
The antibody response against Staphylococcus aureus antigens was quantitated in mice immunized with live staphylococci, the fibronectin‐binding protein, clumping factor, or saline by means of enzyme‐linked immunosorbent assay. Immunization with purified clumping factor induced a significant increase in antibody levels, while the fibronectin‐binding protein gave a poor response. All mice immunized with live S. aureus developed a high antibody level. The immunization of mice with live S. aureus or clumping factor resulted in an increased resistance towards staphylococcal intraperitoneal infection.