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Induction of Local Immunity to Group a Streptococci Type M50 in Mice by Non‐Type‐Specific Mechanisms
Author(s) -
Kurl Daya N.,
StjernquistDesatnik Anna,
Schalén Claés,
Christensen Poul
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1985.tb02909.x
Subject(s) - type (biology) , immunity , group (periodic table) , biology , immunology , immune system , physics , ecology , quantum mechanics
The possibility of inducing immunity in the upper respiratory tract against type M50 group A streptococci was studied in mice. The M50 type exhibited an LD 100 a of 10 5 colony‐forming units (CFU) when administered intranasally (i.n.), and of 10 7 CFU when introduced intraperitoneally (i.p.). I.n. administered vaccines prepared from M types 12, 18, 30, 49, 50 and 55 were equally efficient in preventing lethal infection after i.n. challenge with type M50. Subcutaneous (s.c.) immunization with type 18 had no effect, whereas s.c. immunization with type 50 was effective against i.n. challenge with type 50. Neither with i.n. nor s.c., did vaccination with type 18 ‐ in contrast to with type 50 ‐ protect against i.p. challenge with type 50. The results strongly suggest that local immunity against M50 group A streptococci can be achieved using a non‐type‐specific mechanism. Once the local barrier had been overcome, protection against systemic infection was type‐specific in accordance with classic concepts.