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Determination of Interpretive Breakpoints for Ceftazidime Disc‐diffusion Susceptibility Testing Using Single‐Strain Regression Analysis
Author(s) -
Petersson Ann Cathrine,
Kronvall Goran
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1985.tb02891.x
Subject(s) - ceftazidime , regression analysis , statistics , linear regression , regression , strain (injury) , diffusion , breakpoint , mathematics , biology , physics , genetics , anatomy , bacteria , gene , pseudomonas aeruginosa , thermodynamics , chromosomal translocation
Interpretive breakpoints for ceftazidime disc‐diffusion susceptibility testing were determined using single‐strain regression analysis (SRA). Regression lines were determined for a total of 58 strains representing 15 species, from inhibition zone diameters obtained for discs containing six different ceftazidime concentrations. Statistical analysis for excluding non‐linearity of test‐results was performed. A minimum of five tests on consecutive days was required for maximal precision of regression analysis according to the SRA‐method. Calculated regression lines showed similarities within individual and groups of bacterial species. A minimum of five strains could be used to represent these groups. Interpretive breakpoints according to recommended MIC‐limits were determined for each species taking into consideration confidence limits for zone correlates of MIC‐values. Single‐strain regression analysis for the determination of interpretive breakpoints for ceftazidime disc‐diffusion susceptibility testing in individual laboratories.