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Fatal Outcome of Splenectomy in Rats With Experimental Biliary Infection
Author(s) -
Tanaka Nobutaka,
Christensen Paul,
Rydén Stefan,
KlöfverStáhl Britten,
Bengmark Stig
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1985.tb02885.x
Subject(s) - splenectomy , medicine , outcome (game theory) , spleen , mathematics , mathematical economics
The effect of splenectomy in normal rats receiving retrograde intrabiliary (RI) or intravenous (IV) injection of 10 5 Escherichia coli was studied. IV injection of the bacteria did not cause any deaths, independent of whether simultaneous ligation of the common bile duct was performed or not. In contrast, RI injection immediately after splenectomy resultet in the death of 9/12 animals although only 1/12 RI‐injected rats with intact spleens died ( p < 0.005 ). The findings might have implications for the performance of splenectomy in patients with combined hepato‐biliary diseases.