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Polyagglutinability Due to Loss of O‐Antigenic Determinants in Pseudomonas Aeruginosa Strains Isolated from Cystic Fibrosis Patients
Author(s) -
Ojeniyi Bente,
Bék Leif,
Høiby Niels
Publication year - 1985
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1985.tb02844.x
Subject(s) - pseudomonas aeruginosa , cystic fibrosis , microbiology and biotechnology , antigen , biology , pseudomonas , medicine , immunology , bacteria , genetics
O‐polyagglutinable P. aeruginosa are prevalent among chronically infected cystic fibrosis patients. In the present work, one O‐group 3, one O‐group 9 and one polyagglutinable 0–3/9 strain were analysed by use of both corresponding group specific antisera against the O‐antigen and polyspecific antisera against all extractable antigens of the 3 strains. Quantitative immunoelectrophoresis and classical tube‐agglutination methods were employed in the analysis. The results showed that the polyagglutinable strain contained 0.1% and the 0–9 strain 1%, respectively, of the O‐antigen‐containing LPS present in the 0–3 strain. It is discussed whether these differences represent a gradual antigenic adjustment to the defence mechanisms of the chronically infected patients.