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NUCLEAR DNA RECORD IN A MALIGNANT RECTAL CARCINOID
Author(s) -
WILANDER ERIK,
GLIMELIUS BENGT,
KRAAZ WOLFGANG,
PONTÉN JAN,
PAHLMAN LARS,
SCHEIBENPFLUG LENA
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1984.tb04413.x
Subject(s) - argentaffin , nuclear dna , lymph node , pathology , cytology , malignant cells , dna , biology , immunocytochemistry , medicine , cancer , biochemistry , genetics , mitochondrial dna , gene
A colo‐rectal resection was performed on a 73‐year‐old woman with a preoperative diagnosis of rectal carcinoma. Morphological examination of the specimen revealed a rectal carcinoid tumor with regional lymph node and liver metastases. Silver stains demonstrated an argyrophil reaction in the tumor cells, but the argentaffin reaction and immunocytochemistry with monoclonal serotonin antibodies were negative. Imprint cytology of the tumor was examined cytofluorometrically and diploid nuclear DNA values were recorded with only few tetraploid cells (< 2%.). It is suggested that diploid nuclear DNA values and a low proliferative activity are characteristic of malignant rectal carcinoids.