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CORRELATION OF ESTROGEN AND PROGESTERONE RECEPTORS AND HISTOLOGICAL GRADE IN HUMAN PRIMARY BREAST CANCER
Author(s) -
ALANKO ARTO,
MAKINEN JUDIT,
SCHEININ THEODOR M.,
TOLPPANEN ESAMATTI,
VIHKO REIJO
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1984.tb04409.x
Subject(s) - estrogen receptor , estrogen , progesterone receptor , receptor , breast cancer , concomitant , medicine , endocrinology , breast carcinoma , oestrogen receptor , mammary gland , biology , cancer , oncology
The relationships between the presence of female sex steroid receptors and their concentrations, and the histological grade were investigated in primary breast carcinoma specimens from 151 patients. The concentrations of estrogen receptor were significantly lower in grade III tumours than in the more differentiated ones from pre‐ and post‐menopausal patients, whereas the same was observed for progesterone receptor concentrations only between grades III and I in post‐menopausal patients. Generally estrogen and progesterone receptor‐positive, estrogen receptor rich tumours frequently belonged to well‐differentiated tumour categories. Whereas most of the tumours belonging to grade III group were receptor‐negative, approximately three fourths of receptor‐negative tumours belonged to grade I and II categories. It is therefore suggested that estrogen receptor‐negativity or low receptor concentrations and grade III histological appearance of breast carcinoma are independent risk indicators, and their concomitant use is recommended in designing treatment strategies for individual patients.