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HUMAN SERUM AND PLASMA INCREASE MOUSE MORTALITY IN STAPHYLOCOCCUS AUREUS INTRAPERITONEAL INFECTION
Author(s) -
ESPERSEN F.,
CLEMMENSEN I.,
RHODES J. M.,
JENSEN K.
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1984.tb02838.x
Subject(s) - staphylococcus aureus , virulence , microbiology and biotechnology , fibrinogen , fibronectin , immune system , staphylococcal infections , intraperitoneal injection , bacteria , blood proteins , strain (injury) , biology , immunology , chemistry , biochemistry , endocrinology , gene , genetics , extracellular matrix , anatomy
The influence of human plasma, serum, purified fibrinogen, and fibronectin on Staphylococcus aureus intraperitoneal infection in non‐immune mice was studied. Mouse mortality was used as a measure of staphylococcal virulence. Both human plasma and serum were shown to enhance the virulence of S.aureus strain E 2371 and strain E 2476 when added to the bacteria before challenge. This effect of serum was unaffected by storage for 24 h at 37 °C or complement‐inactivation for 1 h at 56 °C. Purified fibrinogen and fibronectin did not influence the S. aureus virulence. It is suggested that the effects of plasma and serum described here might play a role in the establishment of S.aureus infections in humans.