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IMMUNOLOGICAL CROSS‐REACTION BETWEEN ANTIGEN Tp‐4 OF TREPONEMA PALLIDUM AND AN ANTIGEN COMMON TO A WIDE RANGE OF BACTERIA
Author(s) -
HINDERSSON PETER,
PETERSEN CARSTEN SAND,
PEDERSEN NILS STRANDBERG,
HØIBY NIELS,
AXELSEN NILS H.
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1984.tb02818.x
Subject(s) - treponema , antigen , syphilis , microbiology and biotechnology , bacteria , cross reactions , cross reactivity , biology , reactivity (psychology) , virology , immunology , chemistry , medicine , pathology , genetics , human immunodeficiency virus (hiv) , alternative medicine
By electro‐immunoprecipitation methods it was shown that antigen Tp—4 of Treponema pallidum , antigen TR‐c of the Reiter treponeme and ‘Common Antigen’ of Pseudomonas aeruginosa are immunologically cross‐reactive. This finding establishes a taxonomic relationship between T. pallidum and a wide range of bacteria. The cross‐reactivity explains some false positive reactions in serodiagnostic treponemal tests for syphilis. The cross‐reactivity may also play a role in a possible ‘normal’ immunity against infection with T. pallidum induced by antigens by the normal human bacterial flora.