Premium
METHYLPREDNISOLONE PULSE THERAPY INDUCED FALL IN NATURAL KILLER CELL ACTIVITY IN RHEUMATOID ARTHRITIS
Author(s) -
PEDERSEN BENTE K.,
BEYER JANNIE M.,
RASMUSSEN ANNIE,
KLARLUND KIM,
PEDERSEN B.N.,
HELIN P.
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1984.tb00094.x
Subject(s) - rheumatoid arthritis , methylprednisolone , medicine , natural killer cell , pulse (music) , cell , immunology , peripheral blood , biology , cytotoxic t cell , computer science , in vitro , telecommunications , biochemistry , genetics , detector
Natural killer (NK) cell activity was studied in 8 patients with classic or definite rheumatoid arthritis (RA) by investigating the killing of K 562 cells by peripheral blood lymphocytes before, during, and after intravenous methylprednisolone pulse therapy (MPPT). MPPT produced a considerable fall in NK activity and after 3 months NK activity was less than half that before MPPT.