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ADHERENCE AND PHAGOCYTOSIS OF YEAST CELLS BY BLOOD MONOCYTES EFFECTS IN VITRO OF A THERAPEUTIC DOXYCYCLINE CONCENTRATION
Author(s) -
ATHLIN LEIF,
DOMELLÖF LENNART,
NORBERG BO
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1984.tb00079.x
Subject(s) - phagocytosis , doxycycline , in vitro , yeast , monocyte , microbiology and biotechnology , macrophage , immunology , cell , phagocytic cell , chemistry , biology , antibiotics , biochemistry
The effect of a therapeutic doxycyline concentration on yeast‐cell phagocytosis by blood monocytes was studied in vitro by means of a fluoresence assay. This method allows discrimination between monocyte‐adherent yeast cells and ingested yeast cells. The adhesive and phagocytic capacity of 50 monocytes was measured in 16 healthy donors. Yeast‐cell adherence was not influenced by doxycycline. In contrast, a slight depression of phagocytosis by doxycycline was suggested. The median difference between doxycyclin‐treated and control monocytes was 30% (p = 0.07). It is reasonable to assume that a possible inhibitory effect of doxycycline on monocyte phagocytosis is negligible in healthy individuals. However, a clinically significant effect cannot be excluded in severely immuno‐compromised patients.