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IgA SUBCLASS DISTRIBUTION IN PARAPROTEINEMIAS: SUGGESTION OF AN IgG‐IgA SUBCLASS SWITCH PATTERN
Author(s) -
HAMMARSTRÖM L.,
MELLSTEDT H.,
PERSSON M. A. A.,
SMITH C. I. E.,
ÅHRE A.
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1984.tb00076.x
Subject(s) - subclass , paraproteins , immunology , immunoglobulin a , antibody , multiple myeloma , medicine , biology , immunoglobulin g , monoclonal antibody , monoclonal
IgA subclass distribution in the serum of 40 patients with IgA multiple myeloma and 10 patients with benign monoclonal gammopathy of the IgA class was determined. All were found to be of the IgA 1 subclass. A review of the literature shows a marked predominance (93%) of IgAl paraproteins, suggesting an under‐representation of IgA2 myelomas. The subclass pattern in 11 double paraproteinemias studied and those previously reported in the literature suggest a pattern of IgG1 ‐ IgA1, IgA1 ‐ IgG4 and possibly also IgG2 ‐ IgA2 switches in malignant cells.