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MONOCYTE/T‐CELL INTERACTIONS IN CON A INDUCED SUPPRESSOR ACTIVITY
Author(s) -
DAVIDSEN BOGI,
KRISTENSEN ERIK
Publication year - 1984
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1984.tb00070.x
Subject(s) - peripheral blood mononuclear cell , suppressor , monocyte , lymphoblast , myeloid derived suppressor cell , immunology , peripheral blood , biology , in vitro , chemistry , cell culture , gene , biochemistry , genetics
It is well documented that peripheral blood mononuclear cells (PBMC) can exert a Con A induced suppressor activity. The PBMC content of monocytes and its impact on registered suppressor activity of PBMC populations was examined. It was found that monocytes were unnecessary for the Con A induction of PBMC, and monocytes exhibited no Con A dependent suppressor potential. Furthermore, the presence of monocytes was found to be unnecessary for the Con A activated lymphocytes in order to exert their suppressor activity against the responder system, i.e. a Con A stimulated lymphoblast‐transformation.