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FERRITIN (FER) IN TESTICULAR GERM CELL TUMOURS
Author(s) -
Jacobsen Grete Krag,
Jacobsen Marianne
Publication year - 1983
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1983.tb02743.x
Subject(s) - seminoma , immunoperoxidase , embryonal carcinoma , germ cell , yolk sac , ferritin , biology , pathology , teratoma , immature teratoma , embryo , germ cell tumors , medicine , cellular differentiation , immunology , antibody , microbiology and biotechnology , chemotherapy , biochemistry , gene , monoclonal antibody , genetics
189 orchidectomy specimens with germ cell tumours were studied for the presence of ferritin (FER) using the indirect immunoperoxidase technique. FER was demonstrated in 93% of seminomas and 90% of non‐seminomas. Various epithelial cell types in embryonal carcinoma (EC), yolk sac tumours (YST) and teratoma (T) were FER positive. Carcinoma‐in‐situ (CIS) which was present in the seminiferous tubules adjacent to the tumours was positively stained for FER in 94% of the specimens whether the tumour was a seminoma or a non‐seminoma indicating a functional relationship of CIS to seminomatous as well as to non‐seminomatous germ cell tumours.