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HISTOPATHOLOGICAL GRADING IN SOFT‐TISSUE TUMOURS
Author(s) -
MyhreJensen O.,
Kaae S.,
Madsen E. HjøLlund,
Sneppen O.
Publication year - 1983
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1983.tb02739.x
Subject(s) - anaplasia , grading (engineering) , soft tissue , soft tissue sarcoma , malignancy , mitotic index , sarcoma , medicine , pathology , histopathology , biology , mitosis , ecology , microbiology and biotechnology
A system for histopathological grading of malignancy in soft‐tissue sarcoma is described in detail, and the importance of the grade of tumour in predicting survival is demonstrated in a consecutive series of 261 surgically treated patients with sarcoma of the somatic soft tissue. Mitosis index is the main discriminating criterion. Delay in fixation, for instance in large specimens, may cause an artificially low mitosis index calling for the need of other criteria, too, reflecting grade of malignancy: cellularity, anaplasia, number of pycnotic and/or fragmented nuclei. There is a significant difference in survival between the three grades, 10 years survival with surgical treatment alone is 97%, 57% and 29% for grades 1, 2 and 3 respectively.