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ORAL SELENIUM INHIBITS SKIN REACTIONS TO UV LIGHT IN HAIRLESS MICE
Author(s) -
Thorling E. B.,
Overvad K.,
Bjerring P.
Publication year - 1983
Publication title -
acta pathologica microbiologica scandinavica series a :pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0164
DOI - 10.1111/j.1699-0463.1983.tb02730.x
Subject(s) - hairless , selenium , chemistry , photoaging , skin reaction , dermatology , pharmacology , medicine , biochemistry , organic chemistry
In different experimental systems oral selenium has a pronounced anti‐carcinogenic effect. This includes both spontaneous and chemically‐induced cancers (1, 2, 3, 6, 7, 8). Our primary objective was to study the effect of selenium on the carcinogenic potential of UV light in hairless mice. Fairly early in these experiments, however, it became obvious that the selenium‐supplemented mice were considerably more resistant to the acute and sub‐acute effects of UV light than were the unsupplemented animals. This was found for the inflammatory reaction as well as for the development of pigmentation. As far as we know, this effect of selenium has not previously been described.