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POPULATION ANALYSIS IN STRAINS OF STAPHYLOCOCCUS AUREUS AND STAPHYLOCOCCUS EPIDERMIDIS
Author(s) -
HANSEN BENTE GAHRN
Publication year - 1983
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1983.tb00071.x
Subject(s) - microbiology and biotechnology , penicillin , staphylococcus epidermidis , staphylococcus aureus , cefotaxime , cephalosporin , antibiotics , cefuroxime , population , biology , medicine , bacteria , genetics , environmental health
Population analyses of susceptibility to cefuroxime and cefotaxime in penicillin‐susceptible, penicillin‐resistant, and methicillin‐resistant strains of Staphylococcus aureus (S. aureus) and Staphylococcus epidermidis (S. epidermidis) were carried out. All strains were clinical isolates. Both antibiotics were shown to be more penicillinase‐stable than cephalothin in studies of the penicillin‐resistant strains of S. aureus , but less stable than methicillin. The studies of penicillin‐resistant strains of S. epidermidis showed no differences in penicillinase‐stability between cephalothin and the new cephalosporins. From the methicillin‐resistant strains of S. aureus and S. epidermidis it was possible to select highly‐resistant mutants against both antibiotics with a frequency of c. 10 ‐5 although MIC determinations had shown the strains to be susceptible.