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INFLUENCE OF BILE ACIDS ON CHOLERA TOXIN‐INDUCED SECRETION IN MOUSE JEJUNUM
Author(s) -
LANGE S.,
HANSSON H. A.,
LÖNNROTH I.
Publication year - 1983
Publication title -
acta pathologica microbiologica scandinavica series b: microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0180
DOI - 10.1111/j.1699-0463.1983.tb00036.x
Subject(s) - cholera toxin , jejunum , secretion , cholera , toxin , microbiology and biotechnology , medicine , chemistry , biology , biochemistry
The influence of bile acids on intestinal secretion induced by cholera toxin (CT) was studied in mice. The secretion was examined in ligated loops after the bile flow had been stopped by ligation of the common bile duct (CD). Bile depletion was found to inhibit both the secretion induced by CT, the degradation of CT, and the binding of CT to epithelial cells – all of which could be restored to normal by the application, before CT challenge, of bile acids in the loops of CD‐ligated mice. Out of the nine bile acids tested, cholic acid, deoxycholic acid and chenodeoxycholic acid were the most potent, their ED 50 values being 0.2, 0.2, and 0.6 mM respectively.