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ANTI‐C‐CARBOHYDRATE ANTIBODIES AFTER PNEUMOCOCCAL VACCINATION
Author(s) -
Pedersen Freddy Karup,
Henrichsen JØRgen,
SØRensen Uffe Skov,
Nielsen Johan Lanng
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01462.x
Subject(s) - antibody , carbohydrate , vaccination , immunology , pneumococcal polysaccharide vaccine , medicine , pneumococcal vaccine , polysaccharide , streptococcus pneumoniae , biology , microbiology and biotechnology , pneumococcal disease , biochemistry , antibiotics
Similar levels of naturally occurring anti‐pneumococcal C‐carbohydrate antibodies were found in 15 splenectomized children, 10 splenectomized adults and 12 healthy adult volunteers by enzymelinked immunosorbent assay. Vaccination with a 14‐valent pneumococcal capsular polysaccharide vaccine (Pneumovax©) that contains approximately 75 μg C‐carbohydrate per dose only led to small anti‐C‐carbohydrate antibody increases; they were significant, however, for all three groups (p < 0.05) but antibody fold increases were below 2 in 34 of the 37 individuals studied.