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QUALITATIVE STUDY ON THE KUPFFER CELLS IN THE LIVER OF ETHANOL‐ AND CARBON TETRACHLORIDE‐TREATED RATS
Author(s) -
Lautenschlager Irmeli,
Väänänen Hannu,
Kulonen Eino
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01461.x
Subject(s) - phagocytosis , carbon tetrachloride , ccl4 , ethanol , kupffer cell , opsonin , chemistry , peripheral blood mononuclear cell , receptor , medicine , endocrinology , biochemistry , biology , immunology , in vitro , organic chemistry
The treatment of rats with ethanol or CCl 4 caused in addition to an increase in numbers, qualitative changes in the Kupffer cells. The rate of phagocytosis of opsonized erythrocytes was greatly increased in the Kupffer cells from CCl 4 ‐treated rats, compared with a slightly decreased phagocytosis in similar cells taken from ethanol‐treated rats. The number of F c‐ receptors per cell was slightly higher in the Kuppffer cells from ethanol‐ and CCl 4 ‐treated rats than in normal rats. Although the nonparenchymal cell fraction from the livers of ethanol‐ and CCl 4 ‐treated rats contained more mononuclear phagocytes than the respective control samples, both the adhering and nonadhering subtractions from the livers of ethanol‐treated rats contained proportionally fewer mononuclear phagocytes following an assessment of adhesiveness than the other samples. No difference in esterase staining was observed between the groups.