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HUMORAL AND CELLULAR IMMUNITY IN TYPHOID AND PARATYPHOID CARRIER STATE, INVESTIGATED BY MEANS OF QUANTITATIVE IMMUNOELECTROPHORESIS AND IN VITRO STIMULATION OF BLOOD LYMPHOCYTES
Author(s) -
Espersen F.,
Mogensen H. H.,
HØIby N.,
HØJ L.,
Greibe J.,
Rasmussen S. N.,
Gaarslev K.,
SALCAgroup Danish
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01453.x
Subject(s) - immunology , salmonella typhi , antibody , typhoid fever , immunity , lymphocyte , humoral immunity , immunoelectrophoresis , in vitro , stimulation , cellular immunity , precipitin , immune system , biology , virology , medicine , endocrinology , biochemistry , escherichia coli , gene
The humoral and cellular immunity of 8 Salmonella carriers and 9 non‐carriers was investigated and compared to findings in normal persons. The antibody response in serum and intestinal secretions was investigated by means of crossed immunoelectrophoresis, and blood lymphocytes were investigated by in vitro stimulation. Both carriers and non‐carriers showed increased levels of precipitating antibodies as well as lymphocyte responses, when compared to normal persons. No differences in the antibody responses either qualitatively or quantitatively were found between carriers and non‐carriers. Only few precipitins could be detected in intestinal secretions. Lymphocyte responses to S. typhi and S. paratyphi were significantly higher in carriers and non‐carriers than in the controls. No significant difference in lymphocyte response to S. typhi, S. paratyphi and mitogens was obtained between carriers and non‐carriers. Thus, the carrier state seems not due to detectable major immunodeficiency.