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LOCALIZATION OF Fcy RECEPTORS IN THE HUMAN CENTRAL NERVOUS SYSTEM
Author(s) -
Nyland Harald,
Nilsen Rune
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01441.x
Subject(s) - choroid plexus , horseradish peroxidase , parenchyma , leptomeninges , central nervous system , pathology , stroma , biology , pia mater , immune system , receptor , chemistry , anatomy , immunohistochemistry , medicine , neuroscience , immunology , biochemistry , enzyme
Immune complexes of horseradish peroxidase (HRP) and rabbit IgG antibodies to HRP were used to study the Fcy receptors in the human central nervous system (CNS). The peroxidase activity was demonstrated with 3,3′‐diaminobenzidine tetrahydrochloride and H 2 O 2 . The majority of the pia and arachnoid cells of the leptomeninges, the stroma cells of the arachnoid granulations and the adventitial cells in the perivascular spaces of the nervous tissue were stained. The villi of the choroid plexus were also stained. By electron microscopy the reaction products were localized to the plasma membranes of the stroma cells and at the basal aspects of the epithelial cells in the choroid villi. In addition, reaction product was demonstrated on pericytes of some of the brain capillaries. The immune complexes did not bind to the brain parenchyma.