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T LYMPHOCYTE SUBPOPULATIONS DEFINED BY MONOCLONAL ANTIBODIES AND FC RECEPTOR BINDING IN RELATION TO IMMUNOSUPPRESSION IN VACCINE‐INDUCED RUBELLA INFECTION
Author(s) -
Arneborn Per,
Biberfeld Gunnel,
Stedingk LarsViktor
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01434.x
Subject(s) - pokeweed mitogen , immunology , monoclonal antibody , vaccination , immunosuppression , antibody , immune system , lymphocyte , t lymphocyte , biology , rubella , cytotoxic t cell , peripheral blood mononuclear cell , virology , fc receptor , immunization , measles , in vitro , biochemistry
Lymphocyte stimulation tests and determination of T lymphocyte subpopulations were undertaken before and 7–11 days after rubella vaccination of healthy subjects. The proliferatory response of blood mononuclear cells to phytohemagglutinin (PHA) and purified protein derivate was suppressed after vaccination, as was also the immunoglobulin production of pokeweed mitogen (PWM) stimulated cultures. After removal of phagocytic cells the response to PHA was still suppressed after vaccination in most cases, but when the cultures were depleted of non‐T lymphocytes the suppression was no longer demonstrable. The proportion of T lymphocytes with receptors for the Fc part of IgG increased after vaccination, whereas there was no significant change of the T lymphocyte subpopulations identified with monoclonal antibodies directed at the suppressor/cytotoxic or helper T cell subsets.