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CYTOTOXICITY OF TEMPORARILY ADHERENT HUMAN MONONUCLEAR BLOOD CELLS:
Author(s) -
Eggen BjØRn Magne
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01429.x
Subject(s) - peripheral blood mononuclear cell , cytotoxic t cell , cytotoxicity , in vitro , cytolysis , microbiology and biotechnology , immunology , biology , chemistry , biochemistry
In monolayers of freshly isolated human mononuclear blood cells. 5–1096 of the adherent cells are non‐monocytic. These cells detach during the first day of in vitro culture. These detached cells exert high cytolytic and cytostatic activities. The detached cells were found to be mostly (90%) non‐monocytic as assessed by cell morphology studies and characterization with respect to membrane markers. The detached cells consited of 40% T‐lymphocytes. 10% B‐lymphocytes and 40% non‐T, non‐B lymphocytes. Thirty‐five percent of the cells were Fc‐receptor‐bearing cells. Following sheep red blood cell (SRBC) rosetting. the cytotoxic cells were found in the non‐SRBC‐rosetting fraction, viz. they were non‐T lymphocytes.