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THE RELATIONSHIP BETWEEN HUMAN T LYMPHOCYTE SUBSETS DEFINED BY MONOCLONAL ANTIBODIES AND BY AVIDITY DIFFERENCES TO SHEEP ERYTHROCYTES
Author(s) -
Hokland P.,
Hokland M.,
Heron I.
Publication year - 1982
Publication title -
acta pathologica microbiologica scandinavica series c: immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.909
H-Index - 88
eISSN - 1600-0463
pISSN - 0108-0202
DOI - 10.1111/j.1699-0463.1982.tb01425.x
Subject(s) - avidity , monoclonal antibody , antigen , cell sorting , antibody , t lymphocyte , monoclonal , biology , immunology , microbiology and biotechnology , flow cytometry
By E‐rosette sedimentation procedures and fluorescence activated cell sorting of monoclonal antibody‐coated T lymphocytes, we have investigated the relationship between the human T lymphocyte subsets defined by the monoclonal antibodies against the T4 and T8 antigens and those defined by avidity differences to sheep erythrocytes. Though a correlation was demonstrated between the T4+ (inducer) cells and the high avidity (»active«) T cells and between the T8+ (suppressor) cells and low avidity T cells, these subsets were far from identical, and it is concluded that the application of monoclonal antibodies represents another valuable and standardized approach for estimating T cell subsets.